PureFTP can cause bizarre behaviour often. Sometimes running in cpanel it could refuse your connection or you could face password authentication problem. I have faced this on my dedicated server many times and could be frustrating sometimes.
Here is how you fix the problem:
1. Login to WHM of Cpanel
2. Restart the PureFTP server
That should fix the problem in most cases:
NOTE: Make sure you have NOT blocked port 21 by firewall before using FTP.
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